Section C

Section C contains data collected from the cognitive tests administered during ASPREE. These were the Modified Mini-Mental State Examination (3MS), Controlled Oral Word Association Test (COWAT), Hopkins Verbal Learning Test (HVLT-R), and the Symbol-Digit Modalities Test (SDMT).

C.1 3MS examination

Description

This section contains data collected from the 3MS (1). The 3MS Examination is a validated questionnaire that is widely used to screen cognitive function. The assessment includes the same items as the Mini-Mental State Examination along with four additional items. It offers a brief assessment of the person’s cognitive function including orientation to time and place, recall, and simple language skills.

Timing of Data Collection

The 3MS was performed at Visit 1, which occurred prior to randomisation during the screening process, at odd year annual visits and at the Milestone Visit.

Summary of Data Dictionary

This section contains continuous and discrete data. Individual scores have been provided for each question on the 3MS as well as the raw overall 3MS score and predicted score adjusted for age and level of education. A 3MS reassessment was required following a 3MS score below 78 or a 10.15 drop below the expected score accompanied with a CES-D 10 score of eight or higher. Reassessment was carried out three months later. A commentary code of 3 has been applied to indicate when a field is not applicable to the participant. For example, where data was not collected because the 3MS was not scheduled to be performed. Variables collected annually have been named sequentially to represent the timing of and sequential manner of data collection.

C.2 Longitudinal COWAT, HVLT-R, SDMT

Description

This section contains data relating to participant cognitive function collected from the COWAT (2), HVLT-R (3), and the SDMT (4). These tests were used to assess the presence of mild cognitive impairment.

The COWAT is a measure of executive function and verbal fluency where participants are asked to generate as many words as possible beginning with the letter F. The HVLT-R is used to assess immediate and delayed recall and delayed recognition and has been widely used in previous studies of cognitive impairment. The SDMT is a non-language based test used to assess executive functioning, specifically of processing speed and activation as well as complex visual scanning.

Timing of Data Collection

The COWAT, HVLT-R and SDMT were performed at Visit 2, which occurred prior to randomisation during the screening process, at odd year annual visits and at the Milestone Visit.

Summary of Data Dictionary

This section contains discrete data only. An overall score for the COWAT and SDMT have been provided for baseline and each annual visit. Scores have been provided for HVLT-R trials one to four as well as the number of true positives and false positives for baseline and each annual visit. A commentary code of 3 has been applied to indicate when a field is not applicable to the participant. For example, where data was not collected because the test was not scheduled to be performed. Variables collected annually have been named sequentially to represent the timing of and sequential manner of data collection.

References

  1. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination. J Clin Psychiatry. 1987 Aug;48(8):314–8.

  2. Ross TP. The reliability of cluster and switch scores for the Controlled Oral Word Association Test. Arch Clin Neuropsychol. 2003 Mar;18(2):153–64.

  3. Benedict RHB, Schretlen D, Groninger L, Brandt J. Hopkins Verbal Learning Test – Revised: Normative Data and Analysis of Inter-Form and Test-Retest Reliability. Clin Neuropsychol. 1998 Feb 1;12(1):43–55.

  4. Smith A, Services (Firm) WP. Symbol digit modalities test : manual [Internet]. Los Angeles, Calif. : Western Psychological Corporation; 2002 [cited 2018 Nov 1]. Available from: https://trove.nla.gov.au/version/42656069

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